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Pharmacokinetic Interactions between the Hormonal Emergency Contraception, Levonorgestrel (Plan B), and Efavirenz
Joint Authors
Cu-Uvin, Susan
Mawhinney, Samantha
Kiser, Jennifer J.
Kwara, Awewura
Carten, Monica L.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objectives.
Compare the Plan B levonorgestrel (LNG) area under the concentration- time curve (AUC12) prior to and with efavirenz (EFV).
Design.
Prospective, open-label, single-arm, equivalence study.
Methods.
Healthy HIV-negative subjects underwent 12 hr intensive pharmacokinetic (PK) sampling following single dose LNG alone and after 14 days of EFV.
Geometric means, Geometric Mean Ratios, and 90% confidence intervals (CI) are reported for PK Parameters.
T-tests were utilized.
Clinical parameters and liver function tests (LFTs) were assessed.
Results.
24 women enrolled and 21 completed the study.
With EFV, LNG AUC12 was reduced 56% (95% CI: 49%, 62%) from 42.9 to 17.8 ng*hr/mL, and maximum concentration (Cmax) was reduced 41% (95% CI: 33%, 50%) from 8.4 to 4.6 ng/mL.
LNG was well tolerated with no grade 3 or 4 treatment-related toxicities.
Conclusions.
EFV significantly reduced LNG exposures.
Higher LNG doses may be required with EFV.
These results reinforce the importance of effective contraception in women taking EFV.
American Psychological Association (APA)
Carten, Monica L.& Kiser, Jennifer J.& Kwara, Awewura& Mawhinney, Samantha& Cu-Uvin, Susan. 2012. Pharmacokinetic Interactions between the Hormonal Emergency Contraception, Levonorgestrel (Plan B), and Efavirenz. Infectious Diseases in Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-448635
Modern Language Association (MLA)
Carten, Monica L.…[et al.]. Pharmacokinetic Interactions between the Hormonal Emergency Contraception, Levonorgestrel (Plan B), and Efavirenz. Infectious Diseases in Obstetrics and Gynecology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-448635
American Medical Association (AMA)
Carten, Monica L.& Kiser, Jennifer J.& Kwara, Awewura& Mawhinney, Samantha& Cu-Uvin, Susan. Pharmacokinetic Interactions between the Hormonal Emergency Contraception, Levonorgestrel (Plan B), and Efavirenz. Infectious Diseases in Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-448635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448635