Guideline Concordant Therapy Prolongs Survival in HER2-Positive Breast Cancer Patients : Results from a Large Population-Based Cohort of a Cancer Registry
Joint Authors
Inwald, E. C.
Gerstenhauer, M.
Zeman, F.
Hofstädter, F.
Koller, Michael
Ortmann, O.
Klinkhammer-Schalke, M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Even though randomized controlled clinical trials demonstrated improved survival by adjuvant trastuzumab treatment of HER2-positive breast cancer patients, data on its effect in clinical routine are scarce.
This study evaluated the use and efficacy of trastuzumab in routine treatment of HER2-positive breast cancer patients.
Data from the clinical cancer registry Regensburg (Germany) were analyzed.
The present study investigated 6,991 female patients with primary invasive breast cancer.
In premenopausal HER2-positive patients a considerable increase of trastuzumab therapy was observed from 58.1% in 2006 to 90.9% in 2011, whereas in postmenopausal patients trastuzumab was rather used on a constant rate of 49.1%.
Best overall survival (OS) was found in HER2/steroid hormone receptor-positive patients receiving guideline concordant treatment with trastuzumab plus chemotherapy (CHT) plus antihormone therapy (AHT) with a 7-year OS rate of 96% compared to the non-trastuzumab group with a 7-year OS rate of 92%.
In multivariable analysis, HER2-positive patients treated with CHT or AHT who did not get trastuzumab, had a worse 7-year OS (65%, P=0.006 versus 79%, P=0.017) than the control groups.
This population-based study demonstrated that guideline concordant use of adjuvant trastuzumab improves OS for HER2-positive breast cancer patients treated in routine clinical care.
American Psychological Association (APA)
Inwald, E. C.& Ortmann, O.& Zeman, F.& Koller, Michael& Hofstädter, F.& Gerstenhauer, M.…[et al.]. 2014. Guideline Concordant Therapy Prolongs Survival in HER2-Positive Breast Cancer Patients : Results from a Large Population-Based Cohort of a Cancer Registry. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-448645
Modern Language Association (MLA)
Inwald, E. C.…[et al.]. Guideline Concordant Therapy Prolongs Survival in HER2-Positive Breast Cancer Patients : Results from a Large Population-Based Cohort of a Cancer Registry. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-448645
American Medical Association (AMA)
Inwald, E. C.& Ortmann, O.& Zeman, F.& Koller, Michael& Hofstädter, F.& Gerstenhauer, M.…[et al.]. Guideline Concordant Therapy Prolongs Survival in HER2-Positive Breast Cancer Patients : Results from a Large Population-Based Cohort of a Cancer Registry. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-448645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448645