Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment
Joint Authors
Malíčková, Karin
Janatková, Ivana
Klamová, Hana
Roth, Zdeněk
Hamšíková, Eva
Šterzl, Ivan
Humlová, Zuzana
Vonka, Vladimír
Králíková, Petra
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-12
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
In the previous paper of ours we compared, prior to start any treatment, a number of immunological parameters in 24 chronic myeloid leukemia patients with the same number of healthy subjects matched by age and sex.
We found significant differences in the levels of immunoglobulins, the C4 component of complement, the C-reactive protein, interleukin 6, the composition of lymphocyte population and the production of some cytokines by stimulated CD3+ cells.
Eleven of these patients were followed longitudinally.
After treatment with hydroxyurea, interferon alpha, imatinib mesylate and dasatinib, or various combinations thereof, hematological remission was achieved in all patients and complete cytogenetic remission in nine of them.
There was a nearly general tendency towards normalization of the abnormalities observed in the patients at their enrollment.
American Psychological Association (APA)
Humlová, Zuzana& Klamová, Hana& Janatková, Ivana& Malíčková, Karin& Králíková, Petra& Šterzl, Ivan…[et al.]. 2010. Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-448646
Modern Language Association (MLA)
Humlová, Zuzana…[et al.]. Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment. Clinical and Developmental Immunology No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-448646
American Medical Association (AMA)
Humlová, Zuzana& Klamová, Hana& Janatková, Ivana& Malíčková, Karin& Králíková, Petra& Šterzl, Ivan…[et al.]. Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-448646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448646