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Lipotoxicity : Effects of Dietary Saturated and Transfatty Acids
Joint Authors
de Piano, Aline
Oller do Nascimento, Claudia Maria da Penha
Oyama, Lila Missae
Ribeiro, Eliane B.
Dâmaso, Ana R.
Estadella, Débora
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The ingestion of excessive amounts of saturated fatty acids (SFAs) and transfatty acids (TFAs) is considered to be a risk factor for cardiovascular diseases, insulin resistance, dyslipidemia, and obesity.
The focus of this paper was to elucidate the influence of dietary SFA and TFA intake on the promotion of lipotoxicity to the liver and cardiovascular, endothelial, and gut microbiota systems, as well as on insulin resistance and endoplasmic reticulum stress.
The saturated and transfatty acids favor a proinflammatory state leading to insulin resistance.
These fatty acids can be involved in several inflammatory pathways, contributing to disease progression in chronic inflammation, autoimmunity, allergy, cancer, atherosclerosis, hypertension, and heart hypertrophy as well as other metabolic and degenerative diseases.
As a consequence, lipotoxicity may occur in several target organs by direct effects, represented by inflammation pathways, and through indirect effects, including an important alteration in the gut microbiota associated with endotoxemia.
Interactions between these pathways may perpetuate a feedback process that exacerbates an inflammatory state.
The importance of lifestyle modification, including an improved diet, is recommended as a strategy for treatment of these diseases.
American Psychological Association (APA)
Estadella, Débora& Oller do Nascimento, Claudia Maria da Penha& Oyama, Lila Missae& Ribeiro, Eliane B.& Dâmaso, Ana R.& de Piano, Aline. 2013. Lipotoxicity : Effects of Dietary Saturated and Transfatty Acids. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-448673
Modern Language Association (MLA)
Estadella, Débora…[et al.]. Lipotoxicity : Effects of Dietary Saturated and Transfatty Acids. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-448673
American Medical Association (AMA)
Estadella, Débora& Oller do Nascimento, Claudia Maria da Penha& Oyama, Lila Missae& Ribeiro, Eliane B.& Dâmaso, Ana R.& de Piano, Aline. Lipotoxicity : Effects of Dietary Saturated and Transfatty Acids. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-448673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448673