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Epo Is Relevant Neither for Microvascular Formation Nor for the New Formation and Maintenance of Mice Skeletal Muscle Fibres in Both Normoxia and Hypoxia
Joint Authors
Launay, Thierry
Agbulut, Onnik
Richalet, Jean-Paul
Beaudry, Michèle
El-Hasnaoui-Saadani, Raja
Hagström, Luciana
Favret, Fabrice
Marchant, Dominique
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Erythropoietin (Epo) and vascular growth factor (VEGF) are known to be involved in the regulation of cellular activity when oxygen transport is reduced as in anaemia or hypoxic conditions.
Because it has been suggested that Epo could play a role in skeletal muscle development, regeneration, and angiogenesis, we aimed to assess Epo deficiency in both normoxia and hypoxia by using an Epo-deficient transgenic mouse model (Epo-TAgh).
Histoimmunology, ELISA and real time RT-PCR did not show any muscle fiber atrophy or accumulation of active HIF-1α but an improvement of microvessel network and an upregulation of VEGFR2 mRNA in Epo-deficient gastrocnemius compared with Wild-Type one.
In hypoxia, both models exhibit an upregulation of VEGF120 and VEGFR2 mRNA but no accumulation of Epo protein.
EpoR mRNA is not up-regulated in both Epo-deficient and hypoxic gastrocnemius.
These results suggest that muscle deconditioning observed in patients suffering from renal failure is not due to Epo deficiency.
American Psychological Association (APA)
Hagström, Luciana& Agbulut, Onnik& El-Hasnaoui-Saadani, Raja& Marchant, Dominique& Favret, Fabrice& Richalet, Jean-Paul…[et al.]. 2010. Epo Is Relevant Neither for Microvascular Formation Nor for the New Formation and Maintenance of Mice Skeletal Muscle Fibres in Both Normoxia and Hypoxia. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-448693
Modern Language Association (MLA)
Hagström, Luciana…[et al.]. Epo Is Relevant Neither for Microvascular Formation Nor for the New Formation and Maintenance of Mice Skeletal Muscle Fibres in Both Normoxia and Hypoxia. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-448693
American Medical Association (AMA)
Hagström, Luciana& Agbulut, Onnik& El-Hasnaoui-Saadani, Raja& Marchant, Dominique& Favret, Fabrice& Richalet, Jean-Paul…[et al.]. Epo Is Relevant Neither for Microvascular Formation Nor for the New Formation and Maintenance of Mice Skeletal Muscle Fibres in Both Normoxia and Hypoxia. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-448693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448693