Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas

Abstract EN

Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features.

In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role.

Nevertheless, microenvironment-related cues have progressively come into focus as true determinants for this process.

The cancer-associated microenvironment is a complex network of nonneoplastic immune and stromal cells embedded in extracellular components, giving rise to a multifarious crosstalk with neoplastic cells towards the induction of a supportive milieu.

The immunological and stromal microenvironments have been classically regarded as essential partners of indolent lymphomas, while considered mainly negligible in the setting of aggressive B-cell lymphomas that, by their nature, are less reliant on external stimuli.

By this paper we try to delineate the cardinal microenvironment-centred dynamics exerting an influence over lymphoid clone progression in aggressive B-cell lymphomas.