Immunologic Characterization of Posthepatitis Cirrhosis Caused by HBV and HCV Infection
Joint Authors
Jin, Qing-Long
Zhang, Hong
Jiang, Yan-Fang
Niu, Jun-Qi
Feng, Xiang-Wei
Li, Wan-Yu
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
No specific treatment can reverse the liver injury in cirrhosis.
This study aims to characterize immune status and correlations between cirrhosis induced by HBV and HCV.
Phenotypes of peripheral blood lymphocyte subsets (T, NK, regulatory T cells) and Th cytokine secretion were analyzed using flow cytometry in 42 HBV-cirrhotic and 40 HCV-cirrhotic patients.
Cirrhotic patients had a lower proportion of CD3+CD8+T cells and NK cells, while the proportion of CD3+CD4+T cells and Treg cells were higher than those of healthy controls.
The levels of Th2 cytokine (IL-6) in cirrhotic patients were increased, while only the Th1 cytokine (IFN-γ) increased in HBV-cirrhotic patients.
These findings show that there is no difference between the cirrhotic groups except in the IFN-γ level.
In cirrhosis, defects in innate, adaptive immune cells are likely regardless of which virus is involved.
A cytokine imbalance may play a role in the development of posthepatitic cirrhosis.
American Psychological Association (APA)
Li, Wan-Yu& Jiang, Yan-Fang& Jin, Qing-Long& Zhang, Hong& Feng, Xiang-Wei& Niu, Jun-Qi. 2010. Immunologic Characterization of Posthepatitis Cirrhosis Caused by HBV and HCV Infection. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-448726
Modern Language Association (MLA)
Li, Wan-Yu…[et al.]. Immunologic Characterization of Posthepatitis Cirrhosis Caused by HBV and HCV Infection. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-448726
American Medical Association (AMA)
Li, Wan-Yu& Jiang, Yan-Fang& Jin, Qing-Long& Zhang, Hong& Feng, Xiang-Wei& Niu, Jun-Qi. Immunologic Characterization of Posthepatitis Cirrhosis Caused by HBV and HCV Infection. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-448726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448726