Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes
Joint Authors
Sytwu, Huey-Kang
Chen, Heng-Yi
Chou, Feng-Cheng
Fang, Mei-Cho
Chen, Shyi-Jou
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Type 1 diabetes (T1D) is an autoimmune disease mediated by T cells that selectively destroy the insulin-producing β cells.
Previous reports based on epidemiological and animal studies have demonstrated that both genetic factors and environmental parameters can either promote or attenuate the progression of autoimmunity.
In recent decades, several inbred rodent strains that spontaneously develop diabetes have been applied to the investigation of the pathogenesis of T1D.
Because the genetic manipulation of mice is well developed (transgenic, knockout, and conditional knockout/transgenic), most studies are performed using the nonobese diabetic (NOD) mouse model.
This paper will focus on the use of genetically manipulated NOD mice to explore the pathogenesis of T1D and to develop potential therapeutic approaches.
American Psychological Association (APA)
Chou, Feng-Cheng& Chen, Heng-Yi& Chen, Shyi-Jou& Fang, Mei-Cho& Sytwu, Huey-Kang. 2013. Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448754
Modern Language Association (MLA)
Chou, Feng-Cheng…[et al.]. Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-448754
American Medical Association (AMA)
Chou, Feng-Cheng& Chen, Heng-Yi& Chen, Shyi-Jou& Fang, Mei-Cho& Sytwu, Huey-Kang. Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448754