MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl6 Mouse
Joint Authors
Jakowec, Michael W.
Wood, Ruth I.
Petzinger, Giselle M.
Antzoulatos, Eleni
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nigrostriatal damage is increased in males relative to females.
While estrogen is neuroprotective in females, less is known about potential protective effects of testosterone in males.
We determined if castration enhances neuronal injury to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Castrates or sham-castrated mice were sacrificed 1 week following injection of MPTP (4×20 mg/kg) or saline (n=11-12/group).
The right striatum was immunostained for tyrosine hydroxylase (TH).
The left hemisphere was stained by Golgi Cox to quantify neuronal morphology in medium spiny neurons (MSNs) of the dorsolateral striatum.
MPTP reduced TH, but there was no effect of castration and no interaction.
For MSN dendritic morphology, MPTP decreased the highest branch order and increased spine density on 2nd-order dendrites.
Castrated males had shorter 5th-order dendrites.
However, there was no interaction between gonadal status and MPTP.
Thus, castration and MPTP exert nonoverlapping effects on MSN morphology with castration acting on distal dendrites and MPTP acting proximally.
American Psychological Association (APA)
Antzoulatos, Eleni& Jakowec, Michael W.& Petzinger, Giselle M.& Wood, Ruth I.. 2011. MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl6 Mouse. Pathology Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-448765
Modern Language Association (MLA)
Antzoulatos, Eleni…[et al.]. MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl6 Mouse. Pathology Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-448765
American Medical Association (AMA)
Antzoulatos, Eleni& Jakowec, Michael W.& Petzinger, Giselle M.& Wood, Ruth I.. MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl6 Mouse. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-448765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448765