Human L-Ficolin (Ficolin-2) and Its Clinical Significance
Joint Authors
Chalmers, James D.
Kilpatrick, David C.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Human L-ficolin (P35, ficolin-2) is synthesised in the liver and secreted into the bloodstream where it is one of the major pattern recognition molecules of plasma/serum.
Like other ficolins, it consists of a collagen-like tail region linked to a fibrinogen-related globular head; a basic triplet subunit arises via a collagen-like triple helix, and this then forms higher multimers (typically a 12-mer, Mr 400K).
Unlike other ficolins, it has a complex set of binding sites arranged within an internal cleft enabling it to recognise a variety of molecular patterns including acetylated sugars and certain 1,3-β-glucans.
It is one of the few molecules known to activate the lectin pathway of complement.
Recently, some disease association studies (at either the DNA or protein level) have implicated L-ficolin in innate immunity, where it might cooperate with pentraxins and collectins.
Emerging lines of evidence point to a role for L-ficolin in respiratory immunity, where its affinity for Pseudomonas aeruginosa could be significant.
American Psychological Association (APA)
Kilpatrick, David C.& Chalmers, James D.. 2012. Human L-Ficolin (Ficolin-2) and Its Clinical Significance. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448803
Modern Language Association (MLA)
Kilpatrick, David C.& Chalmers, James D.. Human L-Ficolin (Ficolin-2) and Its Clinical Significance. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-448803
American Medical Association (AMA)
Kilpatrick, David C.& Chalmers, James D.. Human L-Ficolin (Ficolin-2) and Its Clinical Significance. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448803