Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase
Joint Authors
Cendrowska-Pinkosz, Monika
Burdan, Franciszek
Matysiak, Wlodzimierz
Korobowicz-Markiewicz, Agnieszka
Iwan, Magdalena
Madej-Czerwonka, Barbara
Dudka, Jaroslaw
Korga, Agnieszka
Jodlowska-Jedrych, Barbara
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Cytochrome P450 NADPH-reductase (P450R), inducible synthase (iNOS) and xanthine oxidase play an important role in the antracycline-related cardiotoxicity.
The expression of P450R and iNOS is regulated by triiodothyronine.
The aim of this study was to evaluate the effect of methimazole-induced hypothyreosis on oxidative stress secondary to doxorubicin administration.
48 hours after methimazole giving cessation, rats were exposed to doxorubicin (2.0, 5.0 and 15 mg/kg).
Blood and heart were collected 4, 48 and 96 h after the drug administration.
Animals exposed exclusively to doxorubicin or untreated ones were also assessed.
The hypothyreosis (0.025% of methimazole) significantly increased the doxorubicin effect on the cardiac carbonyl group and they may increase the glutathione level.
An insignificant effect of methimazole was noticed in case of the cardiac lipid peroxidation product, the amount of DNA oxidative damages, iNOS and xanthine oxidase-enzymes responsible for red-ox activation of doxorubicin.
However, the concentration of P450R was affected by a lower dose of methimazole in rats administered with doxorubicin.
Since in rats receiving doxorubicin changes in oxidative stress caused by methimazole were not accompanied by elevation of bioreductive enzymes, it may be concluded that these changes in the oxidative stress were not related to the tested enzymes.
American Psychological Association (APA)
Dudka, Jaroslaw& Burdan, Franciszek& Korga, Agnieszka& Iwan, Magdalena& Madej-Czerwonka, Barbara& Cendrowska-Pinkosz, Monika…[et al.]. 2012. Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448850
Modern Language Association (MLA)
Dudka, Jaroslaw…[et al.]. Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-448850
American Medical Association (AMA)
Dudka, Jaroslaw& Burdan, Franciszek& Korga, Agnieszka& Iwan, Magdalena& Madej-Czerwonka, Barbara& Cendrowska-Pinkosz, Monika…[et al.]. Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448850