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Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown
Joint Authors
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Systemic lupus erythematosus is characterized by a breakdown of self-tolerance and production of autoantibodies.
Kidney involvement (i.e., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney, leading to acute or chronic renal failure.
Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis.
This paper describes the mechanisms through which autoantibodies interact with resident renal cells and how this interaction plays a part in disease pathogenesis that ultimately leads to structural and functional alterations in lupus nephritis.
American Psychological Association (APA)
Yung, Susan& Chan, Tak Mao. 2012. Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-448853
Modern Language Association (MLA)
Yung, Susan& Chan, Tak Mao. Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown. Clinical and Developmental Immunology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-448853
American Medical Association (AMA)
Yung, Susan& Chan, Tak Mao. Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-448853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448853