![](/images/graphics-bg.png)
Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells
Joint Authors
Knorre, Dmitry A.
Sokolov, Svyatoslav S.
Severin, Fedor F.
Popadin, Konstantin Y.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Eukaryotic cells contain dynamic mitochondrial filaments: they fuse and divide.
Here we summarize data on the protein machinery driving mitochondrial dynamics in yeast and also discuss the factors that affect the fusion-fission balance.
Fission is a general stress response of cells, and in the case of yeast this response appears to be prosurvival.
At the same time, even under normal conditions yeast mitochondria undergo continuous cycles of fusion and fission.
This seems to be a futile cycle and also expensive from the energy point of view.
Why does it exist? Benefits might be the same as in the case of sexual reproduction.
Indeed, mixing and separating of mitochondrial content allows mitochondrial DNA to segregate and recombine randomly, leading to high variation in the numbers of mutations per individual mitochondrion.
This opens a possibility for effective purifying selection-elimination of mitochondria highly contaminated by deleterious mutations.
The beneficial action presumes a mechanism for removal of defective mitochondria.
We argue that selective mitochondrial autophagy or asymmetrical distribution of mitochondria during cell division could be at the core of such mechanism.
American Psychological Association (APA)
Knorre, Dmitry A.& Popadin, Konstantin Y.& Sokolov, Svyatoslav S.& Severin, Fedor F.. 2013. Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-448866
Modern Language Association (MLA)
Knorre, Dmitry A.…[et al.]. Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-448866
American Medical Association (AMA)
Knorre, Dmitry A.& Popadin, Konstantin Y.& Sokolov, Svyatoslav S.& Severin, Fedor F.. Roles of Mitochondrial Dynamics under Stressful and Normal Conditions in Yeast Cells. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-448866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448866