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Erythroblast Enucleation
Joint Authors
Crispino, John D.
Keerthivasan, Ganesan
Wickrema, Amittha
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells.
Mammalian erythrocytes extrude their nucleus prior to entering circulation, likely to impart flexibility and improve the ability to traverse through capillaries that are half the size of erythrocytes.
Recently, there have been many advances in our understanding of the mechanisms underlying mammalian erythrocyte enucleation.
This review summarizes these advances, discusses the possible future directions in the field, and evaluates the prospects for improved ex vivo production of red blood cells.
American Psychological Association (APA)
Keerthivasan, Ganesan& Wickrema, Amittha& Crispino, John D.. 2011. Erythroblast Enucleation. Stem Cells International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-448899
Modern Language Association (MLA)
Keerthivasan, Ganesan…[et al.]. Erythroblast Enucleation. Stem Cells International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-448899
American Medical Association (AMA)
Keerthivasan, Ganesan& Wickrema, Amittha& Crispino, John D.. Erythroblast Enucleation. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-448899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448899