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Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning
Joint Authors
Helmstetter, Fred J.
Jarome, Timothy J.
Lonergan, Mary E.
Gafford, Georgette M.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Memory consolidation requires transcription and translation of new protein.
Arc, an effector immediate early gene, and zif268, a regulatory transcription factor, have been implicated in synaptic plasticity underlying learning and memory.
This study explored the temporal expression profiles of these proteins in the rat hippocampus following fear conditioning.
We observed a time-dependent increase of Arc protein in the dorsal hippocampus 30-to-90-minute post training, returning to basal levels at 4 h.
Zif268 protein levels, however, gradually increased at 30-minute post training before peaking in expression at 60 minute.
The timing of hippocampal Arc and zif268 expression coincides with the critical period for protein synthesis-dependent memory consolidation following fear conditioning.
However, the expression of Arc protein appears to be driven by context exploration, whereas, zif268 expression may be more specifically related to associative learning.
These findings suggest that altered Arc and zif268 expression are related to neural plasticity during the formation of fear memory.
American Psychological Association (APA)
Lonergan, Mary E.& Gafford, Georgette M.& Jarome, Timothy J.& Helmstetter, Fred J.. 2010. Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning. Neural Plasticity،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-448905
Modern Language Association (MLA)
Lonergan, Mary E.…[et al.]. Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning. Neural Plasticity No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-448905
American Medical Association (AMA)
Lonergan, Mary E.& Gafford, Georgette M.& Jarome, Timothy J.& Helmstetter, Fred J.. Time-Dependent Expression of Arc and Zif268 after Acquisition of Fear Conditioning. Neural Plasticity. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-448905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448905