The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation
Joint Authors
Richert, Lysiane
Vidal, Isabelle
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We aimed at reviewing the various uses of Nude mouse for the development of liver deficiency models and evaluation of efficacy of hepatic cell xenotransplantation.
The first part records the large range of liver deficiency models that can be developed in Nude mice: surgical partial hepatectomy, acute toxic liver deficiency, chronic cirrhosis, and transgenic liver injury.
The second part tackles the outcome of rat hepatocyte as well as human cell transplantation, both mature hepatocyte and hepatic progenitor, into Nude mouse submitted to liver injury.
Results are discussed and compared to other available immunodeficient mouse models.
The issue of humanized liver creation is also addressed.
Altogether, these results show that Nude mouse appears to be a suitable small animal model to expand our insight into liver cell engraftment and regeneration.
American Psychological Association (APA)
Vidal, Isabelle& Richert, Lysiane. 2012. The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448914
Modern Language Association (MLA)
Vidal, Isabelle& Richert, Lysiane. The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation. International Journal of Hepatology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-448914
American Medical Association (AMA)
Vidal, Isabelle& Richert, Lysiane. The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448914