Low-Dose Chemotherapy with Insulin (Insulin Potentiation Therapy) in Combination with Hormone Therapy for Treatment of Castration-Resistant Prostate Cancer
Joint Authors
Gavrilov, Veselin
Damyanov, Christo
Gerasimova, Desislava
Maslev, Ivan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To evaluate the results and quality of life of patients with resistant of castration-resistant tumors previously treated with Insulin-potentiation therapy (IPT) combined with hormone therapy.
Materials and methods.
Sixteen patients with metastasis prostate tumors after bilateral castration, androgenic blockade, and progression of the disease were observed during the study.
The patients were divided into two groups: group A consisting of 8 patients treated with low-dose chemotherapy Epirubicin, Vinblastine, and Cyclophosphamide combined with LHRH agonist and group B consisting of another 8 patients treated with low-dose chemotherapy Docetaxel combined with LHRH agonist.
Results.
The overall (groups A and B) results concerning PSA after the sixth IPT show partial effect in 8 out of 16 (50%) patients, stabilization in 4 out of 16 (25%), and progression in 4 out of 16 (25%).
The median survival for all treated patients is 11,7 months (range 3–30 months).
During the treatment no significant side effects were observed, and no lethal cases occurred.
Conclusion.
In spite of the small number of the treated patients with castration-resistant prostate tumors, the preliminary results are promising and this gives us hope and expectations for future serious multicenter research over the possibilities for routine implementation of IPTLD.
American Psychological Association (APA)
Damyanov, Christo& Gerasimova, Desislava& Maslev, Ivan& Gavrilov, Veselin. 2012. Low-Dose Chemotherapy with Insulin (Insulin Potentiation Therapy) in Combination with Hormone Therapy for Treatment of Castration-Resistant Prostate Cancer. ISRN Urology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-448920
Modern Language Association (MLA)
Damyanov, Christo…[et al.]. Low-Dose Chemotherapy with Insulin (Insulin Potentiation Therapy) in Combination with Hormone Therapy for Treatment of Castration-Resistant Prostate Cancer. ISRN Urology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-448920
American Medical Association (AMA)
Damyanov, Christo& Gerasimova, Desislava& Maslev, Ivan& Gavrilov, Veselin. Low-Dose Chemotherapy with Insulin (Insulin Potentiation Therapy) in Combination with Hormone Therapy for Treatment of Castration-Resistant Prostate Cancer. ISRN Urology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-448920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448920