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Identification of HN-1-Peptide Target in Head and Neck Squamous Cell Carcinoma Cells
Joint Authors
Idler, Christin
Bernkop-Schnuerch, Andreas
Dudas, Jozsef
Riechelmann, Herbert
Sprinzl, Georg
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The HN-1 module was previously reported to ensure efficient targeting of head and neck squamous cell carcinoma (HNSCC).
Aim of this work was to indentify the target of HN-1.
Targeting of HN-1 peptide was compared in normal epithelial cells (BEAS-2B) and in HNSCC tumor cells (SCC-25 and Detroit 562).
Experimental, cell culture, cell polarity, and adhesion conditions were tested; structure models of peptides were created.
Indeed, HN-1 was able to target HNSCC tumor cells in the previously published conditions.
The targeting efficiency of immortalized normal epithelial cells was significantly lower.
Nevertheless, in other experimental conditions the binding was less efficient and not specific.
A scrambled sequence of HN-1, with altered order of amino acids showed even better targeting efficiency than HN-1.
HN-1 was only uptaken in adherent cells, not in suspension.
In conclusion, HN-1-peptide-targeting is not based on sequence specificity, but more on electrostatic interactions with the cell surface of the tumor cells.
American Psychological Association (APA)
Dudas, Jozsef& Idler, Christin& Sprinzl, Georg& Bernkop-Schnuerch, Andreas& Riechelmann, Herbert. 2011. Identification of HN-1-Peptide Target in Head and Neck Squamous Cell Carcinoma Cells. ISRN Oncology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-448930
Modern Language Association (MLA)
Dudas, Jozsef…[et al.]. Identification of HN-1-Peptide Target in Head and Neck Squamous Cell Carcinoma Cells. ISRN Oncology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-448930
American Medical Association (AMA)
Dudas, Jozsef& Idler, Christin& Sprinzl, Georg& Bernkop-Schnuerch, Andreas& Riechelmann, Herbert. Identification of HN-1-Peptide Target in Head and Neck Squamous Cell Carcinoma Cells. ISRN Oncology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-448930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448930