Alzheimer's Disease : A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner
Author
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-29
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Herpes simplex is implicated in Alzheimer's disease and viral infection produces Alzheimer's disease like pathology in mice.
The virus expresses proteins containing short contiguous amino acid stretches (5–9aa “vatches” = viralmatches) homologous to APOE4, clusterin, PICALM, and complement receptor 1, and to over 100 other gene products relevant to Alzheimer's disease, which are also homologous to proteins expressed by other pathogens implicated in Alzheimer's disease.
Such homology, reiterated at the DNA level, suggests that gene association studies have been tracking infection, as well as identifying key genes, demonstrating a role for pathogens as causative agents.
Vatches may interfere with the function of their human counterparts, acting as dummy ligands, decoy receptors, or via interactome interference.
They are often immunogenic, and antibodies generated in response to infection may target their human counterparts, producing protein knockdown, or generating autoimmune responses that may kill the neurones in which the human homologue resides, a scenario supported by immune activation in Alzheimer's disease.
These data may classify Alzheimer's disease as an autoimmune disorder created by pathogen mimicry of key Alzheimer's disease-related proteins.
It may well be prevented by vaccination and regular pathogen detection and elimination, and perhaps stemmed by immunosuppression or antibody adsorption-related therapies.
American Psychological Association (APA)
Carter, Chris. 2010. Alzheimer's Disease : A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-448954
Modern Language Association (MLA)
Carter, Chris. Alzheimer's Disease : A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-448954
American Medical Association (AMA)
Carter, Chris. Alzheimer's Disease : A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-448954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448954