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Spectrophotometric Determination of N-Acetyl-L-Cysteine and N-(2-Mercaptopropionyl)-Glycine in Pharmaceutical Preparations
Joint Authors
Kukoc-Modun, Lea
Radić, Njegomir
Source
International Journal of Analytical Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A simple spectrophotometric method for the determination of N-acetyl-L-cysteine (NAC) and N-(2-mercaptopropionyl)glycine (MPG) in pharmaceutical preparations was developed, validated, and used.
The proposed equilibrium method is based on a coupled two-step redox and complexation reaction.
In the first step, Fe(III) is reduced to Fe(II) by NAC or MPG.
Subsequently, Fe(II) is complexed with 2,4,6-tripyridyl-s-triazine (TPTZ).
Several analytical parameters of the method were optimized for NAC and MPG analysis in the concentration range from 1.0 μM to 100.0 μM.
Regression analysis of the calibration data showed a good correlation coefficient (0.9999).
The detection limit of the method was 0.14 μM for NAC and 0.13 μM for MPG.
The method was successfully applied to quantify NAC and MPG in pharmaceutical preparations.
No interferences were observed from common pharmaceutical excipients.
American Psychological Association (APA)
Kukoc-Modun, Lea& Radić, Njegomir. 2011. Spectrophotometric Determination of N-Acetyl-L-Cysteine and N-(2-Mercaptopropionyl)-Glycine in Pharmaceutical Preparations. International Journal of Analytical Chemistry،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-448973
Modern Language Association (MLA)
Kukoc-Modun, Lea& Radić, Njegomir. Spectrophotometric Determination of N-Acetyl-L-Cysteine and N-(2-Mercaptopropionyl)-Glycine in Pharmaceutical Preparations. International Journal of Analytical Chemistry No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-448973
American Medical Association (AMA)
Kukoc-Modun, Lea& Radić, Njegomir. Spectrophotometric Determination of N-Acetyl-L-Cysteine and N-(2-Mercaptopropionyl)-Glycine in Pharmaceutical Preparations. International Journal of Analytical Chemistry. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-448973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448973