Early Life Adversity as a Risk Factor for Fibromyalgia in Later Life
Joint Authors
Low, Lucie A.
Schweinhardt, Petra
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The impact of early life events is increasingly becoming apparent, as studies investigate how early childhood can shape long-term physiology and behaviour.
Fibromyalgia (FM), which is characterised by increased pain sensitivity and a number of affective co-morbidities, has an unclear etiology.
This paper discusses risk factors from early life that may increase the occurrence or severity of FM in later life: pain experience during neonatal life causes long-lasting changes in nociceptive circuitry and increases pain sensitivity in the older organism; premature birth and related stressor exposure cause lasting changes in stress responsivity; maternal deprivation affects anxiety-like behaviours that may be partially mediated by epigenetic modulation of the genome—all these adult phenotypes are strikingly similar to symptoms displayed by FM sufferers.
In addition, childhood trauma and exposure to substances of abuse may cause lasting changes in developing neurotransmitter and endocrine circuits that are linked to anxiety and stress responses.
American Psychological Association (APA)
Low, Lucie A.& Schweinhardt, Petra. 2011. Early Life Adversity as a Risk Factor for Fibromyalgia in Later Life. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-448983
Modern Language Association (MLA)
Low, Lucie A.& Schweinhardt, Petra. Early Life Adversity as a Risk Factor for Fibromyalgia in Later Life. Pain Research and Treatment No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-448983
American Medical Association (AMA)
Low, Lucie A.& Schweinhardt, Petra. Early Life Adversity as a Risk Factor for Fibromyalgia in Later Life. Pain Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-448983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448983