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The Role of PTEN in Tumor Angiogenesis
Joint Authors
Huynh-Do, Uyen
Rodriguez, Stéphane
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
During the past 20 years, the phosphatase and tensin homolog PTEN has been shown to be involved in major physiological processes, and its mutation or loss is often associated with tumor formation.
In addition PTEN regulates angiogenesis not only through its antagonizing effect on the PI3 kinase pathway mainly, but also through some phosphatase-independent functions.
In this paper we delineate the role of this powerful tumor suppressor in tumor angiogenesis and dissect the underlying molecular mechanisms.
Furthermore, it appears that, in a number of cancers, the PTEN status determines the response to chemotherapy, highlighting the need to monitor PTEN expression and to develop PTEN-targeted therapies.
American Psychological Association (APA)
Rodriguez, Stéphane& Huynh-Do, Uyen. 2011. The Role of PTEN in Tumor Angiogenesis. Journal of Oncology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-449015
Modern Language Association (MLA)
Rodriguez, Stéphane& Huynh-Do, Uyen. The Role of PTEN in Tumor Angiogenesis. Journal of Oncology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-449015
American Medical Association (AMA)
Rodriguez, Stéphane& Huynh-Do, Uyen. The Role of PTEN in Tumor Angiogenesis. Journal of Oncology. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-449015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449015