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Effects of Stress and MDMA on Hippocampal Gene Expression
Joint Authors
Gudelsky, Gary A.
Weber, Georg F.
Yamamoto, Bryan K.
Johnson, Bethann N.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
MDMA (3,4-methylenedioxymethamphetamine) is a substituted amphetamine and popular drug of abuse.
Its mood-enhancing short-term effects may prompt its consumption under stress.
Clinical studies indicate that MDMA treatment may mitigate the symptoms of stress disorders such as posttraumatic stress syndrome (PTSD).
On the other hand, repeated administration of MDMA results in persistent deficits in markers of serotonergic (5-HT) nerve terminals that have been viewed as indicative of 5-HT neurotoxicity.
Exposure to chronic stress has been shown to augment MDMA-induced 5-HT neurotoxicity.
Here, we examine the transcriptional responses in the hippocampus to MDMA treatment of control rats and rats exposed to chronic stress.
MDMA altered the expression of genes that regulate unfolded protein binding, protein folding, calmodulin-dependent protein kinase activity, and neuropeptide signaling.
In stressed rats, the gene expression profile in response to MDMA was altered to affect sensory processing and responses to tissue damage in nerve sheaths.
Subsequent treatment with MDMA also markedly altered the genetic responses to stress such that the stress-induced downregulation of genes related to the circadian rhythm was reversed.
The data support the view that MDMA-induced transcriptional responses accompany the persistent effects of this drug on neuronal structure/function.
In addition, MDMA treatment alters the stress-induced transcriptional signature.
American Psychological Association (APA)
Weber, Georg F.& Johnson, Bethann N.& Yamamoto, Bryan K.& Gudelsky, Gary A.. 2014. Effects of Stress and MDMA on Hippocampal Gene Expression. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-449028
Modern Language Association (MLA)
Weber, Georg F.…[et al.]. Effects of Stress and MDMA on Hippocampal Gene Expression. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-449028
American Medical Association (AMA)
Weber, Georg F.& Johnson, Bethann N.& Yamamoto, Bryan K.& Gudelsky, Gary A.. Effects of Stress and MDMA on Hippocampal Gene Expression. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-449028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449028