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Prevention of Peritoneal Metastases from Colon Cancer in High-Risk Patients : Preliminary Results of Surgery plus Prophylactic HIPEC
Joint Authors
Sibio, Simone
Accarpio, Fabio
Di Giorgio, Angelo
Sammartino, Paolo
Rosati, Maria Sofia
Cornali, Tommaso
Cardi, Maurizio
Biacchi, Daniele
Mingazzini, Pietro
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The study compared the outcome in patients with advanced colonic cancer at high risk of peritoneal metastases (mucinous or signet-ring cell) without peritoneal or systemic spread, treated with standard colectomy or a more aggressive combined surgical approach.
The study included patients with colonic cancer with clinical T3/T4, any N, M0, and mucinous or signet ring cell histology.
The 25 patients in the experimental group underwent hemicolectomy, omentectomy, bilateral adnexectomy, hepatic round ligament resection, and appendectomy, followed by HIPEC.
The control group comprised 50 patients treated with standard surgical resection during the same period in the same hospital by different surgical teams.
Outcome data, morbidity, peritoneal recurrence rate, and overall, and disease-free survival, were compared.
Peritoneal recurrence developed in 4% of patients in the experimental group and 22% of controls without increasing morbidity (P<0.05).
Actuarial overall survival curves disclosed no significant differences, whereas actuarial disease-free survival curves showed a significant difference between groups (36.8 versus 21.9 months, P<0.01).
A more aggressive preventive surgical approach combined with HIPEC reduces the incidence of peritoneal recurrence in patients with advanced mucinous colonic cancer and also significantly increases disease-free survival compared with a homogeneous control group treated with a standard surgical approach without increasing morbidity.
American Psychological Association (APA)
Sammartino, Paolo& Sibio, Simone& Biacchi, Daniele& Cardi, Maurizio& Accarpio, Fabio& Mingazzini, Pietro…[et al.]. 2012. Prevention of Peritoneal Metastases from Colon Cancer in High-Risk Patients : Preliminary Results of Surgery plus Prophylactic HIPEC. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-449038
Modern Language Association (MLA)
Sammartino, Paolo…[et al.]. Prevention of Peritoneal Metastases from Colon Cancer in High-Risk Patients : Preliminary Results of Surgery plus Prophylactic HIPEC. Gastroenterology Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-449038
American Medical Association (AMA)
Sammartino, Paolo& Sibio, Simone& Biacchi, Daniele& Cardi, Maurizio& Accarpio, Fabio& Mingazzini, Pietro…[et al.]. Prevention of Peritoneal Metastases from Colon Cancer in High-Risk Patients : Preliminary Results of Surgery plus Prophylactic HIPEC. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-449038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449038