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Cytoskeleton-Associated Protein 4 : Functions Beyond the Endoplasmic Reticulum in Physiology and Disease
Joint Authors
Tuffy, Kevin M.
Planey, Sonia Lobo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cytoskeleton-associated protein 4 (CKAP4; also known as p63, CLIMP-63, or ERGIC-63) is a 63 kDa, reversibly palmitoylated and phosphorylated, type II transmembrane (TM) protein, originally identified as a resident of the endoplasmic reticulum (ER)/Golgi intermediate compartment (ERGIC).
When localized to the ER, a major function of CKAP4 is to anchor rough ER to microtubules, organizing the overall structure of ER with respect to the microtubule network.
There is also steadily accumulating evidence for diverse roles for CKAP4 localized outside the ER, including data demonstrating functionality of cell surface forms of CKAP4 in various cell types and of CKAP4 in the nucleus.
We will review the recent studies that provide evidence for the existence of CKAP4 in multiple cellular compartments (i.e., ER, plasma membrane, and the nucleus) and discuss CKAP4’s role in the regulation of various physiological and pathological processes, such as interstitial cystitis, drug-induced cytotoxicity, pericullar proteolytic activity, and lung lipid homeostasis.
American Psychological Association (APA)
Tuffy, Kevin M.& Planey, Sonia Lobo. 2012. Cytoskeleton-Associated Protein 4 : Functions Beyond the Endoplasmic Reticulum in Physiology and Disease. ISRN Cell Biology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-449089
Modern Language Association (MLA)
Tuffy, Kevin M.& Planey, Sonia Lobo. Cytoskeleton-Associated Protein 4 : Functions Beyond the Endoplasmic Reticulum in Physiology and Disease. ISRN Cell Biology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-449089
American Medical Association (AMA)
Tuffy, Kevin M.& Planey, Sonia Lobo. Cytoskeleton-Associated Protein 4 : Functions Beyond the Endoplasmic Reticulum in Physiology and Disease. ISRN Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-449089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449089