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Marrow Stromal Cell Infusion Rescues Hematopoiesis in Lethally Irradiated Mice despite Rapid Clearance after Infusion
Joint Authors
Balakrishnan, Ilango
Pillai, Manoj M.
Yang, Xiaodong
Torok-Storb, Beverly
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Marrow stromal cells (MSCs, also termed mesenchymal stem cells) have been proposed as a promising cellular therapy for tissue injury including radiation-induced marrow failure, but evidence for a direct effect is lacking.
To assess the effects of MSCs on survival after lethal irradiation, we infused syngeneic MSCs (either as immortalized MSCs clones or primary MSCs) intravenously into wild-type C57/Bl6 mice within 24 hours of lethal total body irradiation (TBI).
Mice receiving either of the MSC preparations had significantly improved survival when compared to controls.
In vivo imaging, immune histochemistry, and RT-PCR employed to detect MSCs indicated that the infused MSCs were predominantly localized to the lungs and rapidly cleared following infusion.
Our results suggest that a single infusion of MSCs can improve survival after otherwise lethal TBI but the effect is not due to a direct interaction with, or contribution to, the damaged marrow by MSCs.
American Psychological Association (APA)
Yang, Xiaodong& Balakrishnan, Ilango& Torok-Storb, Beverly& Pillai, Manoj M.. 2012. Marrow Stromal Cell Infusion Rescues Hematopoiesis in Lethally Irradiated Mice despite Rapid Clearance after Infusion. Advances in Hematology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-449111
Modern Language Association (MLA)
Yang, Xiaodong…[et al.]. Marrow Stromal Cell Infusion Rescues Hematopoiesis in Lethally Irradiated Mice despite Rapid Clearance after Infusion. Advances in Hematology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-449111
American Medical Association (AMA)
Yang, Xiaodong& Balakrishnan, Ilango& Torok-Storb, Beverly& Pillai, Manoj M.. Marrow Stromal Cell Infusion Rescues Hematopoiesis in Lethally Irradiated Mice despite Rapid Clearance after Infusion. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-449111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449111