The Cytoplasm-to-Vacuole Targeting Pathway : A Historical Perspective
Joint Authors
Umekawa, Midori
Klionsky, Daniel J.
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
From today’s perspective, it is obvious that macroautophagy (hereafter autophagy) is an important pathway that is connected to a range of developmental and physiological processes.
This viewpoint, however, is relatively recent, coinciding with the molecular identification of autophagy-related (Atg) components that function as the protein machinery that drives the dynamic membrane events of autophagy.
It may be difficult, especially for scientists new to this area of research, to appreciate that the field of autophagy long existed as a “backwater” topic that attracted little interest or attention.
Paralleling the development of the autophagy field was the identification and analysis of the cytoplasm-to-vacuole targeting (Cvt) pathway, the only characterized biosynthetic route that utilizes the Atg proteins.
Here, we relate some of the initial history, including some never-before-revealed facts, of the analysis of the Cvt pathway and the convergence of those studies with autophagy.
American Psychological Association (APA)
Umekawa, Midori& Klionsky, Daniel J.. 2012. The Cytoplasm-to-Vacuole Targeting Pathway : A Historical Perspective. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-449123
Modern Language Association (MLA)
Umekawa, Midori& Klionsky, Daniel J.. The Cytoplasm-to-Vacuole Targeting Pathway : A Historical Perspective. International Journal of Cell Biology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-449123
American Medical Association (AMA)
Umekawa, Midori& Klionsky, Daniel J.. The Cytoplasm-to-Vacuole Targeting Pathway : A Historical Perspective. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-449123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449123