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The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis
Joint Authors
Shuid, Ahmad Nazrun
Ima-Nirwana, Soelaiman
Mohamed, Norazlina
Muhammad, Norliza
Source
Advances in Pharmacological Sciences
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There is growing evidence that inflammation may be one of the causal factors of osteoporosis.
Several cytokines such as IL-1, IL-6, RANKL, OPG, and M-CSF were implicated in the pathogenesis of osteoporosis.
These cytokines are important determinants of osteoclast differentiation and its bone resorptive activity.
Anticytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss.
Several animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent osteoporosis in rat models by suppressing IL-1 and IL-6.
Free radicals are known to activate transcription factor NFκB which leads to the production of bone resorbing cytokines.
Vitamin E, a potent antioxidant, may be able to neutralise free radicals before they could activate NFκB, therefore suppressing cytokine production and osteoporosis.
Vitamin E has also been shown to inhibit COX-2, the enzyme involved in inflammatory reactions.
Of the two types of vitamin E studied, tocotrienol seemed to be better than tocopherol in terms of its ability to suppress bone-resorbing cytokines.
American Psychological Association (APA)
Shuid, Ahmad Nazrun& Mohamed, Norazlina& Muhammad, Norliza& Ima-Nirwana, Soelaiman. 2011. The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis. Advances in Pharmacological Sciences،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-449129
Modern Language Association (MLA)
Shuid, Ahmad Nazrun…[et al.]. The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis. Advances in Pharmacological Sciences No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-449129
American Medical Association (AMA)
Shuid, Ahmad Nazrun& Mohamed, Norazlina& Muhammad, Norliza& Ima-Nirwana, Soelaiman. The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis. Advances in Pharmacological Sciences. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-449129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449129