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Synthesis, Spectral Characterization, and Antiproliferative Studies of Mixed Ligand Titanium Complexes of Adamantylamine
Joint Authors
Kumar, Nitesh
Awasthi, Pamita
Kaushal, Raj
Chaudhary, Ashun
Arora, Saroj
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
Titanium complexes have been synthesized by the reaction between titanium tetrachloride (TiCl4), respective bidentate ligand [4,4′ -dimethoxy-2,2′ -bipyridine (bpome), 6,6′-dimethyl-2,2′-bipyridine (dpme), 1,2-diaminocyclohexane (dach), 1,10-phenanthroline (phen), and benzoylacetone (bzac)], and adamantylamine (ada) in 1 : 2 : 2 molar ratios, respectively.
The structure of synthesized complexes was confirmed using elemental analysis, FTIR, UV-visible, 1H NMR, and mass spectrometry techniques.
The nanocrystalline nature of complexes was confirmed by powder XRD study.
The complexes were evaluated for cytotoxic potential in HeLa (cervical), C6 (glioma), and CHO (Chinese hamster ovarian) cell lines.
The complex E was found to be more effective cytotoxic agent against HeLa cell line with an IC50 value of 4.06 µM.
Furthermore, the effect of synthesized complexes was studied on different stages of the cell cycle in CHO cells.
All complexes exhibited the dose dependent increase in cytotoxicity.
The results have shown an increase in sub-G0 population with increase in concentration which is an indicative measure of apoptosis.
American Psychological Association (APA)
Kaushal, Raj& Kumar, Nitesh& Chaudhary, Ashun& Arora, Saroj& Awasthi, Pamita. 2014. Synthesis, Spectral Characterization, and Antiproliferative Studies of Mixed Ligand Titanium Complexes of Adamantylamine. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-449148
Modern Language Association (MLA)
Kaushal, Raj…[et al.]. Synthesis, Spectral Characterization, and Antiproliferative Studies of Mixed Ligand Titanium Complexes of Adamantylamine. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-449148
American Medical Association (AMA)
Kaushal, Raj& Kumar, Nitesh& Chaudhary, Ashun& Arora, Saroj& Awasthi, Pamita. Synthesis, Spectral Characterization, and Antiproliferative Studies of Mixed Ligand Titanium Complexes of Adamantylamine. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-449148
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449148