Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats
Joint Authors
Subramaian, P.
Bharti, Vijay K.
Srivastava, Rajendra Swaroop
Pandi-Perumal, Seithikurippu
Warren Spence, D.
Brown, Gregory M.
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The cerebral epiphysis (pineal gland) secrets melatonin and number of other proteins and peptides.
It was thus hypothesized that antioxidant properties of epiphyseal proteins and melatonin could potentially benefit from exogenous therapies.
In view of the therapeutic potential of these proteins, the present experiment was conducted to investigate the effect of buffalo epiphyseal proteins (BEP, at 100 μg/kg BW, i.p.) and melatonin (MEL, at 10 mg/kg BW, i.p) on changes in hepatic and renal antioxidant enzymes of adult female Wistar rats.
Buffalo epiphyseal proteins significantly (P<.05) increased hepatic lipid peroxidation (LPO), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), reduced glutathione (GSH), and renal LPO, catalase (CAT), GR, GSH, GPx levels as compared to control animals.
Similarly, MEL treatment significantly (P<.05) up-regulated hepatic SOD and GPx activity, whereas CAT, GR, GPx, and GSH levels in renal tissues were increased while SOD and LPO remained unaffected.
Buffalo epiphyseal protein treatment produced greater effects on hepatic GPx and renal CAT and GSH levels than did MEL.
These findings support the conclusion that buffalo epiphyseal proteins and melatonin activate a number of antioxidant mechanisms in hepatic and renal tissues.
American Psychological Association (APA)
Bharti, Vijay K.& Srivastava, Rajendra Swaroop& Subramaian, P.& Warren Spence, D.& Pandi-Perumal, Seithikurippu& Brown, Gregory M.. 2011. Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-449158
Modern Language Association (MLA)
Bharti, Vijay K.…[et al.]. Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats. International Journal of Nephrology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-449158
American Medical Association (AMA)
Bharti, Vijay K.& Srivastava, Rajendra Swaroop& Subramaian, P.& Warren Spence, D.& Pandi-Perumal, Seithikurippu& Brown, Gregory M.. Cerebral Epiphyseal Proteins and Melatonin Modulate the Hepatic and Renal Antioxidant Defense of Rats. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-449158
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449158