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Targeting HDACs : A Promising Therapy for Alzheimer's Disease
Joint Authors
Dai, Xue-Ling
Xu, Ke
Jiang, Zhao-Feng
Huang, Han-Chang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Epigenetic modifications like DNA methylation and histone acetylation play an important role in a wide range of brain disorders.
Histone deacetylases (HDACs) regulate the homeostasis of histone acetylation.
Histone deacetylase inhibitors, which initially were used as anticancer drugs, are recently suggested to act as neuroprotectors by enhancing synaptic plasticity and learning and memory in a wide range of neurodegenerative and psychiatric disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD).
To reveal the physiological roles of HDACs may provide us with a new perspective to understand the mechanism of AD and to develop selective HDAC inhibitors.
This paper focuses on the recent research progresses of HDAC proteins and their inhibitors on the roles of the treatment for AD.
American Psychological Association (APA)
Xu, Ke& Dai, Xue-Ling& Huang, Han-Chang& Jiang, Zhao-Feng. 2011. Targeting HDACs : A Promising Therapy for Alzheimer's Disease. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-449196
Modern Language Association (MLA)
Xu, Ke…[et al.]. Targeting HDACs : A Promising Therapy for Alzheimer's Disease. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-449196
American Medical Association (AMA)
Xu, Ke& Dai, Xue-Ling& Huang, Han-Chang& Jiang, Zhao-Feng. Targeting HDACs : A Promising Therapy for Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-449196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449196