FDG-PETCT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas
Joint Authors
Dry, Sarah M.
Weber, Wolfgang A.
Czernin, Johannes
Tap, William D.
Eilber, Fritz C.
Benz, Matthias R.
Phelps, Michael E.
Seeger, Leanne L.
Allen-Auerbach, Martin S.
Eckardt, Jeffrey J.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
The aim of this study was to prospectively evaluate whether FDG-PET allows an accurate assessment of histopathologic response to neoadjuvant treatment in adult patients with primary bone sarcomas.
Methods.
Twelve consecutive patients with resectable, primary high grade bone sarcomas were enrolled prospectively.
FDG-PET/CT imaging was performed prior to the initiation and after completion of neoadjuvant treatment.
Imaging findings were correlated with histopathologic response.
Results.
Histopathologic responders showed significantly more pronounced decreases in tumor FDG-SUVmax from baseline to late follow up than non-responders (64±19% versus 29±30 %, resp.; P=.03).
Using a 60% decrease in tumor FDG-uptake as a threshold for metabolic response correctly classified 3 of 4 histopathologic responders and 7 of 8 histopathologic non-responders as metabolic responders and non-responders, respectively (sensitivity, 75%; specificity, 88%).
Conclusion.
These results suggest that changes in FDG-SUVmax at the end of neoadjuvant treatment can identify histopathologic responders and non-responders in adult primary bone sarcoma patients.
American Psychological Association (APA)
Benz, Matthias R.& Czernin, Johannes& Tap, William D.& Eckardt, Jeffrey J.& Seeger, Leanne L.& Allen-Auerbach, Martin S.…[et al.]. 2010. FDG-PETCT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas. Sarcoma،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-449214
Modern Language Association (MLA)
Benz, Matthias R.…[et al.]. FDG-PETCT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas. Sarcoma No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-449214
American Medical Association (AMA)
Benz, Matthias R.& Czernin, Johannes& Tap, William D.& Eckardt, Jeffrey J.& Seeger, Leanne L.& Allen-Auerbach, Martin S.…[et al.]. FDG-PETCT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas. Sarcoma. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-449214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449214