PLGA Microspheres Incorporated Gelatin Scaffold : Microspheres Modulate Scaffold Properties
Joint Authors
Maiti, Tapas K.
Banerjee, Indranil
Mishra, Debasish
Source
International Journal of Biomaterials
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Freeze drying is one of the popular methods of fabrication for poly(lactide-co-glycolide) (PLGA) microspheres incorporated polymer scaffolds.
However, the consequence of microspheres incorporation on physical and biological properties of scaffold has not been studied yet.
In this study, attempt has been made to characterize the effect of PLGA microsphere incorporation on the physical properties of freeze-dried gelatin scaffold and its influence on cytocompatibility.
Scaffolds loaded with varying amount of PLGA microspheres (10%, 1%, 0.1% w/w) were subjected to microarchitecture analysis, swelling, porosity, mechanical properties, biodegradation, cell adhesion, and cell proliferation studies.
Results revealed that an increase in percentage loading of microspheres reduced the pore size and uniformity of the pore structure.
Moreover, loading of PLGA microspheres up to 1% w/w significantly increased porosity, swelling, and mechanical properties of the scaffold but variations were not proportional for 10% w/w loading.
Results also showed that PLGA microspheres have no significant effect on cell adhesion but influenced the growth kinetics.
American Psychological Association (APA)
Banerjee, Indranil& Mishra, Debasish& Maiti, Tapas K.. 2009. PLGA Microspheres Incorporated Gelatin Scaffold : Microspheres Modulate Scaffold Properties. International Journal of Biomaterials،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-449225
Modern Language Association (MLA)
Banerjee, Indranil…[et al.]. PLGA Microspheres Incorporated Gelatin Scaffold : Microspheres Modulate Scaffold Properties. International Journal of Biomaterials No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-449225
American Medical Association (AMA)
Banerjee, Indranil& Mishra, Debasish& Maiti, Tapas K.. PLGA Microspheres Incorporated Gelatin Scaffold : Microspheres Modulate Scaffold Properties. International Journal of Biomaterials. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-449225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449225