Comprehensive Proteomic Profiling of Aldehyde Dehydrogenases in Lung Adenocarcinoma Cell Lines
Joint Authors
Taguchi, Ayumu
Misek, David E.
Chin, Alice
Hanash, Samir
Schliekelman, Mark
Wong, Chee-Hong
Kuick, Rork
Zhang, Qing
Source
International Journal of Proteomics
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
We have explored the potential of proteomic profiling to contribute to the delineation of the range of expression and subcellular localization of aldehyde dehydrogenases (ALDHs) in lung adenocarcinoma.
In-depth quantitative proteomics was applied to 40 lung adenocarcinoma cell lines resulting in the identification of the known members of the ALDH family.
Substantial heterogeneity in the level and occurrence of ALDHs in total lysates and on the cell surface and in their release into the culture media was observed based on mass spectrometry counts.
A distinct pattern of expression of ALDHs was observed in cells exhibiting epithelial features relative to cells exhibiting mesenchymal features.
Strikingly elevated levels of ALDH1A1 were observed in two cell lines.
We also report on the occurrence of an immune response to ALDH1A1 in lung cancer.
American Psychological Association (APA)
Zhang, Qing& Taguchi, Ayumu& Schliekelman, Mark& Wong, Chee-Hong& Chin, Alice& Kuick, Rork…[et al.]. 2011. Comprehensive Proteomic Profiling of Aldehyde Dehydrogenases in Lung Adenocarcinoma Cell Lines. International Journal of Proteomics،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-449264
Modern Language Association (MLA)
Zhang, Qing…[et al.]. Comprehensive Proteomic Profiling of Aldehyde Dehydrogenases in Lung Adenocarcinoma Cell Lines. International Journal of Proteomics No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-449264
American Medical Association (AMA)
Zhang, Qing& Taguchi, Ayumu& Schliekelman, Mark& Wong, Chee-Hong& Chin, Alice& Kuick, Rork…[et al.]. Comprehensive Proteomic Profiling of Aldehyde Dehydrogenases in Lung Adenocarcinoma Cell Lines. International Journal of Proteomics. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-449264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449264