An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer
Joint Authors
Silva, Patrícia Manuela
Fonseca, Joana
Moura, Inês Moranguinho
Reis, Rita Margarida
Monteiro, Luís Silva
Marques, Sandra
Bousbaa, Hassan
Teixeira, José Henrique
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Abnormal chromosome number, or aneuploidy, is a common feature of human solid tumors, including oral cancer.
Deregulated spindle assembly checkpoint (SAC) is thought as one of the mechanisms that drive aneuploidy.
In normal cells, SAC prevents anaphase onset until all chromosomes are correctly aligned at the metaphase plate thereby ensuring genomic stability.
Significantly, the activity of this checkpoint is compromised in many cancers.
While mutations are rather rare, many tumors show altered expression levels of SAC components.
Genomic alterations such as aneuploidy indicate a high risk of oral cancer and cancer-related mortality, and the molecular basis of these alterations is largely unknown.
Yet, our knowledge on the status of SAC components in oral cancer remains sparse.
In this review, we address the state of our knowledge regarding the SAC defects and the underlying molecular mechanisms in oral cancer, and discuss their therapeutic relevance, focusing our analysis on the core components of SAC and its target Cdc20.
American Psychological Association (APA)
Teixeira, José Henrique& Silva, Patrícia Manuela& Reis, Rita Margarida& Moura, Inês Moranguinho& Marques, Sandra& Fonseca, Joana…[et al.]. 2014. An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-449297
Modern Language Association (MLA)
Teixeira, José Henrique…[et al.]. An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-449297
American Medical Association (AMA)
Teixeira, José Henrique& Silva, Patrícia Manuela& Reis, Rita Margarida& Moura, Inês Moranguinho& Marques, Sandra& Fonseca, Joana…[et al.]. An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-449297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449297