Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro
Joint Authors
Liang, Ying
Wang, Xian
Guan, Youfei
Gao, Yanxiang
Sun, Weiliang
Kong, Wei
Feng, Juan
Zhou, Zhou
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis.
Recent findings suggest that enhanced activity of interleukin-17 (IL-17) producing T helper 17 cells (Th17 cells) plays an important role in autoimmune diseases and inflammatory diseases.
Previous papers have revealed that a lipid-lowering synthetic ligand of peroxisome proliferator-activated receptor α (PPARα), fenofibrate, alleviates both atherosclerosis and a few nonlipid-associated autoimmune diseases such as autoimmune colitis and multiple sclerosis.
However, the link between fenofibrate and Th17 cells is lacking.
In the present study, we hypothesized that fenofibrate inhibited the differentiation of Th17 cells.
Our results showed that fenofibrate inhibited transforming growth factor-β (TGF-β) and IL-6-induced differentiation of Th17 cells in vitro.
However, other PPARα ligands such as WY14643, GW7647 and bezafibrate did not show any effect on Th17 differentiation, indicating that this effect of fenofibrate might be PPARα independent.
Furthermore, our data showed that fenofibrate reduced IL-21 production and STAT3 activation, a critical signal in the Th17 differentiation.
Thus, by ameliorating the differentiation of Th17 cells, fenofibrate might be beneficial for autoimmunity and inflammatory diseases.
American Psychological Association (APA)
Zhou, Zhou& Sun, Weiliang& Liang, Ying& Gao, Yanxiang& Kong, Wei& Guan, Youfei…[et al.]. 2012. Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro. PPAR Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-449329
Modern Language Association (MLA)
Zhou, Zhou…[et al.]. Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro. PPAR Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-449329
American Medical Association (AMA)
Zhou, Zhou& Sun, Weiliang& Liang, Ying& Gao, Yanxiang& Kong, Wei& Guan, Youfei…[et al.]. Fenofibrate Inhibited the Differentiation of T Helper 17 Cells In Vitro. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-449329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449329