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Arginine Vasopressin-Independent Mechanism of Impaired Water Excretion in a Patient with Sarcoidosis Complicated by Central Diabetes Insipidus and Glucocorticoid Deficiency
Joint Authors
Yamagami, Keiko
Yoshioka, Katsunobu
Tanaka, Nagaaki
Inoue, Takeshi
Hosoi, Masayuki
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A 28-year-old man was admitted to our hospital because of reduced livido and increased fatigability.
Four months before admission, he noticed polyuria, which was gradually relieved by admission.
Magnetic resonance imaging revealed enhancing lesion centrally in the pituitary stalk.
Biopsy from the skin revealed noncaseating granuloma composed of epithelioid cells, and a diagnosis of sarcoidosis was made.
Although plasma arginine vasopressin (AVP) was undetectable after administration of hypertonic saline, urinary output was within normal range (1.5 to 2.2 L/day).
The urine osmolality became above plasma levels during the hypertonic saline test.
Hormonal provocative tests revealed partial glucocorticoid deficiency.
Soon after the glucocorticoid therapy was begun, moderate polyuria (from 3.5–4.0 liters daily) occurred.
At this time, plasma AVP was undetectable, and urine osmolality was consistently below plasma levels during the hypertonic saline test.
In conclusion, we showed in human study that masked diabetes insipidus could be mediated by AVP-independent mechanisms.
American Psychological Association (APA)
Yoshioka, Katsunobu& Tanaka, Nagaaki& Yamagami, Keiko& Inoue, Takeshi& Hosoi, Masayuki. 2011. Arginine Vasopressin-Independent Mechanism of Impaired Water Excretion in a Patient with Sarcoidosis Complicated by Central Diabetes Insipidus and Glucocorticoid Deficiency. Case Reports in Medicine،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-449348
Modern Language Association (MLA)
Yoshioka, Katsunobu…[et al.]. Arginine Vasopressin-Independent Mechanism of Impaired Water Excretion in a Patient with Sarcoidosis Complicated by Central Diabetes Insipidus and Glucocorticoid Deficiency. Case Reports in Medicine No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-449348
American Medical Association (AMA)
Yoshioka, Katsunobu& Tanaka, Nagaaki& Yamagami, Keiko& Inoue, Takeshi& Hosoi, Masayuki. Arginine Vasopressin-Independent Mechanism of Impaired Water Excretion in a Patient with Sarcoidosis Complicated by Central Diabetes Insipidus and Glucocorticoid Deficiency. Case Reports in Medicine. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-449348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449348