Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity
Joint Authors
Velusami, Chandrasekaran Chinampudur
Agarwal, Amit
Mookambeswaran, Vijayalakshmi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
N.
nucifera is one among the important medicinal plants assessed for its antiobesity action in various preclinical models.
The present study was aimed at investigating the antiobesity effect of methanol and successive water extracts of petals of N.
nucifera by studying its effect on adipogenesis, adipolysis, lipase, serotonin (5-HT2C), cannabinoid (CNR2), melanocyte concentrating hormone (MCHR1), and melanocortin (MC4R) receptors.
Both methanol and successive water extracts of N.
nucifera petals had an effect on inhibition of lipid storage in adipocytes and on increasing lipolysis.
N.
nucifera petal methanol extract exhibited the concentration-dependent inhibitory effect on lipase activity with an IC50 value of 47 µg/mL.
N.
nucifera petal extracts showed evident agonist and antagonist activity towards 5-HT2C and CNR2 receptors, respectively, while it showed no effect towards MCHR1 and MC4R receptors.
Overall, methanol extract of N.
nucifera petals showed better activity than successive water extract.
American Psychological Association (APA)
Velusami, Chandrasekaran Chinampudur& Agarwal, Amit& Mookambeswaran, Vijayalakshmi. 2013. Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-449354
Modern Language Association (MLA)
Velusami, Chandrasekaran Chinampudur…[et al.]. Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-449354
American Medical Association (AMA)
Velusami, Chandrasekaran Chinampudur& Agarwal, Amit& Mookambeswaran, Vijayalakshmi. Effect of Nelumbo nucifera Petal Extracts on Lipase, Adipogenesis, Adipolysis, and Central Receptors of Obesity. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-449354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449354