Hypofractionated Stereotactic Radiotherapy after Transarterial Chemoembolisation Failure in an Unresectable Hepatocellular Carcinoma : A Case Presentation

Abstract EN

Introduction.

Transarterial chemoembolization is the first-line treatment in unresectable hepatocellular carcinoma.

There is no standard treatment after transarterial chemoembolization failure.

We report the case of a patient with advanced hepatocellular carcinoma who showed a complete response and a long cancer control with hypofractionated stereotactic radiotherapy after transarterial chemoembolization failure.

Case Presentation.

A 70-year-old Caucasian woman was treated with transarterial chemoembolization for advanced hepatocellular, but no cancer control was obtained.

A hypofractionated stereotactic radiotherapy was planned delivering 40 Gy in 5 fractions.

A dramatic reduction in alpha-fetoprotein was observed.

Contrast-enhanced ultrasonography at 1 and 2 months showed large necrotic areas.

Computerised tomography scan showed a 90% objective tumour response, then a complete remission at 3 and 6 months after treatment, respectively.

Status of patient remained unchanged for 2 years.

Conclusions.

Hypofractionated stereotactic radiotherapy can improve survival and prognosis of unresectable hepatocellular carcinoma patient.