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Evaluation of Clinical Interest of Anti-Aquaporin-4 Autoantibody Followup in Neuromyelitis Optica
Joint Authors
Collongues, Nicolas
Vincent, Thierry
Chanson, Jean-Baptiste
Rudolf, Gabrielle
de Seze, Jerome
Alame, Melissa
Fleury, Marie
Blanc, Frédéric
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Neuromyelitis optica (NMO) is an autoimmune disease in which a specific biomarker named NMO-IgG and directed against aquaporin-4 (AQP4) has been found.
A correlation between disease activity and anti-AQP4 antibody (Ab) serum concentration or complement-mediated cytotoxicity has been reported, but the usefulness of longitudinal evaluation of these parameters remains to be evaluated in actual clinical practice.
Thirty serum samples from 10 NMO patients positive for NMO-IgG were collected from 2006 to 2011.
Anti-AQP4 Ab serum concentration and complement-mediated cytotoxicity were measured by flow cytometry using two quantitative cell-based assays (CBA) and compared with clinical parameters.
We found a strong correlation between serum anti-AQP4 Ab concentration and complement-mediated cytotoxicity (P<0.0001).
Nevertheless, neither relapse nor worsening of impairment level was closely associated with a significant increase in serum Ab concentration or cytotoxicity.
These results suggest that complement-mediated serum cytotoxicity assessment does not provide extra insight compared to anti-AQP4 Ab serum concentration.
Furthermore, none of these parameters appears closely related to disease activity and/or severity.
Therefore, in clinical practice, serum anti-AQP4 reactivity seems not helpful as a predictive biomarker in the followup of NMO patients as a means of predicting the onset of a relapse and adapting the treatment accordingly.
American Psychological Association (APA)
Chanson, Jean-Baptiste& Alame, Melissa& Collongues, Nicolas& Blanc, Frédéric& Fleury, Marie& Rudolf, Gabrielle…[et al.]. 2013. Evaluation of Clinical Interest of Anti-Aquaporin-4 Autoantibody Followup in Neuromyelitis Optica. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-449386
Modern Language Association (MLA)
Chanson, Jean-Baptiste…[et al.]. Evaluation of Clinical Interest of Anti-Aquaporin-4 Autoantibody Followup in Neuromyelitis Optica. Clinical and Developmental Immunology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-449386
American Medical Association (AMA)
Chanson, Jean-Baptiste& Alame, Melissa& Collongues, Nicolas& Blanc, Frédéric& Fleury, Marie& Rudolf, Gabrielle…[et al.]. Evaluation of Clinical Interest of Anti-Aquaporin-4 Autoantibody Followup in Neuromyelitis Optica. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-449386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449386