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Liposomal Nasal Spray versus Guideline-Recommended Steroid Nasal Spray in Patients with Chronic Rhinosinusitis : A Comparison of Tolerability and Quality of Life
Joint Authors
Klimek, Ludger
Pfaar, Oliver
Shah-Hosseini, Kija
Eitenmüller, Anna
Mösges, Ralph
Piano, Lisa
Böhm, Myriam
Glowania, Andreas
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To investigate the tolerability and impact on quality of life of liposomal nasal spray compared to guideline-recommended steroid-based therapy in patients with chronic rhinosinusitis.
Symptom reduction and use of antisymptomatic medication were also examined.
Methods.
In this monocenter, prospective, controlled, open, and noninterventional study, 60 patients with chronic rhinosinusitis were treated with liposomal nasal spray and 30 patients received steroid-based therapy.
The study comprised five visits occurring at intervals of two to four weeks.
Efficacy was determined according to the sinusitis symptom score documented daily.
The polyp score was recorded at the initial and final visits.
Tolerability was determined through the Nasal Spray Evaluation Questionnaire, and quality of life was ascertained with the SNOT-20 Score.
Results.
Both treatments achieved a significant reduction of sinusitis symptoms (P<0.05) and also rhinoscopic improvement (P<0.05).
The majority of patients assessed the treatments as “good” or “very good,” and the quality of life improved significantly (P<0.05).
There was no significant difference in symptom reduction, QoL, and endoscopic exams between both treatments.
Conclusion.
The treatment of chronic rhinosinusitis with liposomal nasal spray results in a similar, significant reduction of symptoms and significant improvement in quality of life as guideline-recommended treatment and is therefore a comparable alternative.
American Psychological Association (APA)
Eitenmüller, Anna& Piano, Lisa& Böhm, Myriam& Shah-Hosseini, Kija& Glowania, Andreas& Pfaar, Oliver…[et al.]. 2014. Liposomal Nasal Spray versus Guideline-Recommended Steroid Nasal Spray in Patients with Chronic Rhinosinusitis : A Comparison of Tolerability and Quality of Life. Journal of Allergy،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-449393
Modern Language Association (MLA)
Eitenmüller, Anna…[et al.]. Liposomal Nasal Spray versus Guideline-Recommended Steroid Nasal Spray in Patients with Chronic Rhinosinusitis : A Comparison of Tolerability and Quality of Life. Journal of Allergy No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-449393
American Medical Association (AMA)
Eitenmüller, Anna& Piano, Lisa& Böhm, Myriam& Shah-Hosseini, Kija& Glowania, Andreas& Pfaar, Oliver…[et al.]. Liposomal Nasal Spray versus Guideline-Recommended Steroid Nasal Spray in Patients with Chronic Rhinosinusitis : A Comparison of Tolerability and Quality of Life. Journal of Allergy. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-449393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449393