Development and Validation of UV-Visible Spectrophotometric Baseline Manipulation Method for Simultaneous Quantitation of Tenofovir Disoproxil Fumarate and Emtricitabine in Pharmaceutical Dosage Form
Joint Authors
Chate, Subhash G.
Kuchekar, Bhanudas S.
Parekar, Sanket R.
Bharande, Pradeep D.
Choudhari, Vishnu P.
Singh, Rajiv R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A simple, economical, precise, and accurate new UV-visible spectrophotometric baseline manipulation method for simultaneous determination of tenofovir disoproxil fumarate (TE) and emtricitabine (EM) in combined tablet dosage form has been developed.
The method is based on baseline manipulation (difference) spectroscopy where amplitudes at 261 and 289.9 nm were selected to determine TE and EM, respectively, in combined formulation, and distilled water was used as solvent.
Both drugs obey Beer’s law in the concentration ranges of 4–20 μg/mL for TE and 6–30 μg/mL for EM.
The results of analysis have been validated statistically, and recovery studies confirmed the accuracy of the proposed method which was carried out by following the ICH guidelines.
American Psychological Association (APA)
Choudhari, Vishnu P.& Parekar, Sanket R.& Chate, Subhash G.& Bharande, Pradeep D.& Singh, Rajiv R.& Kuchekar, Bhanudas S.. 2012. Development and Validation of UV-Visible Spectrophotometric Baseline Manipulation Method for Simultaneous Quantitation of Tenofovir Disoproxil Fumarate and Emtricitabine in Pharmaceutical Dosage Form. Journal of Spectroscopy،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-449424
Modern Language Association (MLA)
Choudhari, Vishnu P.…[et al.]. Development and Validation of UV-Visible Spectrophotometric Baseline Manipulation Method for Simultaneous Quantitation of Tenofovir Disoproxil Fumarate and Emtricitabine in Pharmaceutical Dosage Form. Journal of Spectroscopy No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-449424
American Medical Association (AMA)
Choudhari, Vishnu P.& Parekar, Sanket R.& Chate, Subhash G.& Bharande, Pradeep D.& Singh, Rajiv R.& Kuchekar, Bhanudas S.. Development and Validation of UV-Visible Spectrophotometric Baseline Manipulation Method for Simultaneous Quantitation of Tenofovir Disoproxil Fumarate and Emtricitabine in Pharmaceutical Dosage Form. Journal of Spectroscopy. 2012. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-449424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449424
