Surgical Treatment of Neuroendocrine Liver Metastases
Joint Authors
Lee, Ser Yee
Ooi, London L. P. J.
Teo, Jin Yao
Cheow, Peng-Chung
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Management of Neuroendocrine liver metastases (NELM) is challenging.
The presence of NELM worsens survival outcome and almost 10% of all liver metastases are neuroendocrine in origin.
There is no firm consensus on the optimal treatment strategy for NELM.
A systematic search of the PubMed database was performed from 1995–2010, to collate the current evidence and formulate a sound management algorithm.
There are 22 case series with a total of 793 patients who had undergone surgery for NELM.
The overall survival ranges from 46–86% at 5 years, 35–79% at 10 years, and the median survival ranges from 52–123 months.
After successful cytoreductive surgery, the mean duration of symptom reduction is between 16–26 months, and the 5-year recurrence/progression rate ranges from 59–76%.
Five studies evaluated the efficacy of a combination cytoreductive strategy reporting survival rate of ranging from 83% at 3 years to 50% at 10 years.
To date, there is no level 1 evidence comparing surgery versus other liver-directed treatment options for NELM.
An aggressive surgical approach, including combination with additional liver-directed procedures is recommended as it leads to long-term survival, significant long-term palliation, and a good quality of life.
A multidisciplinary approach should be established as the platform for decision making.
American Psychological Association (APA)
Lee, Ser Yee& Cheow, Peng-Chung& Teo, Jin Yao& Ooi, London L. P. J.. 2012. Surgical Treatment of Neuroendocrine Liver Metastases. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-449427
Modern Language Association (MLA)
Lee, Ser Yee…[et al.]. Surgical Treatment of Neuroendocrine Liver Metastases. International Journal of Hepatology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-449427
American Medical Association (AMA)
Lee, Ser Yee& Cheow, Peng-Chung& Teo, Jin Yao& Ooi, London L. P. J.. Surgical Treatment of Neuroendocrine Liver Metastases. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-449427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449427