Adenine Nucleotide Translocase, Mitochondrial Stress, and Degenerative Cell Death
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Mitochondria are intracellular organelles involved in ATP synthesis, apoptosis, calcium signaling, metabolism, and the synthesis of critical metabolic cofactors.
Mitochondrial dysfunction is associated with age-related degenerative diseases.
How mitochondrial dysfunction causes cell degeneration is not well understood.
Recent studies have shown that mutations in the adenine nucleotide translocase (Ant) cause aging-dependent degenerative cell death (DCD) in yeast, which is sequentially manifested by inner membrane stress, mitochondrial DNA (mtDNA) loss, and progressive loss of cell viability.
Ant is an abundant protein primarily involved in ADP/ATP exchange across the mitochondrial inner membrane.
It also mediates basal proton leak and regulates the mitochondrial permeability transition pore.
Missense mutations in the human Ant1 cause several degenerative diseases which are commonly manifested by fractional mtDNA deletions.
Multiple models have been proposed to explain the Ant1-induced pathogenesis.
Studies from yeast have suggested that in addition to altered nucleotide transport properties, the mutant proteins cause a global stress on the inner membrane.
The mutant proteins likely interfere with general mitochondrial biogenesis in a dominant-negative manner, which secondarily destabilizes mtDNA.
More recent work revealed that the Ant-induced DCD is suppressed by reduced cytosolic protein synthesis.
This finding suggests a proteostatic crosstalk between mitochondria and the cytosol, which may play an important role for cell survival during aging.
American Psychological Association (APA)
Liu, Yaxin& Chen, Xin Jie. 2013. Adenine Nucleotide Translocase, Mitochondrial Stress, and Degenerative Cell Death. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449450
Modern Language Association (MLA)
Liu, Yaxin& Chen, Xin Jie. Adenine Nucleotide Translocase, Mitochondrial Stress, and Degenerative Cell Death. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-449450
American Medical Association (AMA)
Liu, Yaxin& Chen, Xin Jie. Adenine Nucleotide Translocase, Mitochondrial Stress, and Degenerative Cell Death. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449450