Neoplastic Meningitis from Solid Tumors : A Prospective Clinical Study in Lombardia and a Literature Review on Therapeutic Approaches
Joint Authors
Fetoni, V.
Salmaggi, A.
Caroli, Manuela
Riva, M.
Gaviani, P.
Imbesi, F.
Merli, R.
De Rossi, M.
Silvani, A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Neoplastic dissemination to the leptomeninges is an increasingly common occurrence in patients with both haematological and solid tumors arising outside the central nervous system.
Both refinement of diagnostic techniques (Magnetic resonance imaging) and increased survival in patients treated with targeted therapies for systemic tumors account for this increased frequency.
Cerebrospinal fluid cytological analysis and MRI confirm clinical diagnosis based on multifocal central nervous system signs/symptoms in a patient with known malignancy.
Overall survival in patients with leptomeningeal neoplastic dissemination from solid tumors is short, rarely exceeding 3-4 months.
However, selected patients may benefit from aggressive therapies, Apart from symptomatic treatment, intrathecal chemotherapy is used, with both free (methotrexate, Thiotepa, AraC) and liposomal antitumor agents (liposomal AraC).
Palliative radiotherapy is indicated only in cases of symptomatic bulky disease, surgery is limited to positioning of Ommaya recervoirs or C5F shunting.
We report clinical data on a cohort of 26 prospectively followed patients with neoplastic leptomeningitis followed in Lombardia, Italy, in 2011.
Prognostic factors and pattern of care are reported.
American Psychological Association (APA)
Silvani, A.& Caroli, Manuela& Gaviani, P.& Fetoni, V.& Merli, R.& Riva, M.…[et al.]. 2013. Neoplastic Meningitis from Solid Tumors : A Prospective Clinical Study in Lombardia and a Literature Review on Therapeutic Approaches. Journal of Drug Delivery،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-449498
Modern Language Association (MLA)
Silvani, A.…[et al.]. Neoplastic Meningitis from Solid Tumors : A Prospective Clinical Study in Lombardia and a Literature Review on Therapeutic Approaches. Journal of Drug Delivery No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-449498
American Medical Association (AMA)
Silvani, A.& Caroli, Manuela& Gaviani, P.& Fetoni, V.& Merli, R.& Riva, M.…[et al.]. Neoplastic Meningitis from Solid Tumors : A Prospective Clinical Study in Lombardia and a Literature Review on Therapeutic Approaches. Journal of Drug Delivery. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-449498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449498