Effect of Berry Extracts and Bioactive Compounds on Fulvestrant (ICI 182,780) Sensitive and Resistant Cell Lines
Joint Authors
Woode, Denzel R.
Seeram, Navindra P.
Li, Liya
Aiyer, Harini S.
Clarke, Robert
Zwart, Alan L.
Sie, Nicole
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Fulvestrant (ICI 182,780; ICI) is approved for the treatment of advanced metastatic breast cancer that is unresponsive to other endocrine therapies.
Berries are frequently consumed for their antioxidant, anti-inflammatory, and anticancer potential.
In this study, we tested the efficacy of two berry extracts (Jamun-EJAE and red raspberry-RRE) and their bioactive compounds (Delphinidin-Del and Ellagic acid-EA) to inhibit cell proliferation with or without a sublethal dose of ICI in various breast cancer cell lines.
ICI-sensitive (LCC1, ZR75-1, and BT474) and -resistant (LCC9, ZR75-1R) cells were subjected to treatment with berry extracts alone (0.1–100 μg/mL) or with a sub-lethal dose of ICI ( Extracts and Del enhanced the effect of ICI in sensitive ZR75-1 and BT474 cells primarily in an additive fashion (measured by relative index (RI)~1). In ZR75-1R cells, both EJAE and RRE synergistically enhanced the effects of ICI (15–50%; P<0.05; RI>1). EA, in doses tested, did not have any significant effects on any of the cell lines. Finally, we found that the extracts were more effective at lower, physiologically relevant concentrations than at higher experimental doses.
American Psychological Association (APA)
Woode, Denzel R.& Aiyer, Harini S.& Sie, Nicole& Zwart, Alan L.& Li, Liya& Seeram, Navindra P.…[et al.]. 2012. Effect of Berry Extracts and Bioactive Compounds on Fulvestrant (ICI 182,780) Sensitive and Resistant Cell Lines. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-449539
Modern Language Association (MLA)
Woode, Denzel R.…[et al.]. Effect of Berry Extracts and Bioactive Compounds on Fulvestrant (ICI 182,780) Sensitive and Resistant Cell Lines. International Journal of Breast Cancer No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-449539
American Medical Association (AMA)
Woode, Denzel R.& Aiyer, Harini S.& Sie, Nicole& Zwart, Alan L.& Li, Liya& Seeram, Navindra P.…[et al.]. Effect of Berry Extracts and Bioactive Compounds on Fulvestrant (ICI 182,780) Sensitive and Resistant Cell Lines. International Journal of Breast Cancer. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-449539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449539