Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model
Joint Authors
Abreo, Fleurette
Boudreaux, Douglas
Clifford, John L.
Ekshyyan, Oleksandr
Phillips, Jeffrey
Moore-Medlin, Tara
Rong, Xiaohua
Lakshmaiah, Raghunatha Reddy
Sonavane, Kunal
Roberts Gill, Jennifer
Nathan, Cherie-Ann O.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Skin squamous cell carcinoma (SCC), the most common cancer in the USA, is a growing problem with the use of tanning booths causing sun-damaged skin.
Antiproliferative effects of curcumin were demonstrated in an aggressive skin cancer cell line SRB12-p9 (P<0.05 compared to control).
Topical formulation was as effective as oral curcumin at suppressing tumor growth in a mouse skin cancer model.
Curcumin at 15 mg administered by oral, topical, or combined formulation significantly reduced tumor growth compared to control (P=0.004).
Inhibition of pAKT, pS6, p-4EBP1, pSTAT3, and pERK1/2 was noted in SRB12-p9 cells post-curcumin treatment compared to control (P<0.05).
Inhibition of pSTAT3 and pERK1/2 was also noted in curcumin-treated groups in vivo.
IHC analysis revealed human tumor specimens that expressed significantly more activated pERK (P=0.006) and pS6 (P<0.0001) than normal skin samples.
This is the first study to compare topical curcumin to oral curcumin.
Our data supports the use of curcumin as a chemopreventive for skin SCC where condemned skin is a significant problem.
Prevention strategies offer the best hope of future health care costs in a disease that is increasing in incidence due to increased sun exposure.
American Psychological Association (APA)
Sonavane, Kunal& Phillips, Jeffrey& Ekshyyan, Oleksandr& Moore-Medlin, Tara& Roberts Gill, Jennifer& Rong, Xiaohua…[et al.]. 2012. Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model. Journal of Skin Cancer،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-449545
Modern Language Association (MLA)
Sonavane, Kunal…[et al.]. Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model. Journal of Skin Cancer No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-449545
American Medical Association (AMA)
Sonavane, Kunal& Phillips, Jeffrey& Ekshyyan, Oleksandr& Moore-Medlin, Tara& Roberts Gill, Jennifer& Rong, Xiaohua…[et al.]. Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model. Journal of Skin Cancer. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-449545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449545