Ischemia Alters the Expression of Connexins in the Aged Human Brain
Joint Authors
Maeda, Tetsuya
Nakase, Taizen
Nagata, Ken
Yoshida, Yasuji
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Although the function of astrocytic gap junctions under ischemia is still under debate, increased expression of connexin 43 (Cx43) has been observed in ischemic brain lesions, suggesting that astrocytic gap junctions could provide neuronal protection against ischemic insult.
Moreover, different connexin subtypes may play different roles in pathological conditions.
We used immunohistochemical analysis to investigate alterations in the expression of connexin subtypes in human stroke brains.
Seven samples, sectioned after brain embolic stroke, were used for the analysis.
Data, evaluated semiquantitatively by computer-assisted densitometry, was compared between the intact hemisphere and ischemic lesions.
The results showed that the coexpression of Cx32 and Cx45 with neuronal markers was significantly increased in ischemic lesions.
Cx43 expression was significantly increased in the colocalization with astrocytes and relatively increased in the colocalization with neuronal marker in ischemic lesions.
Therefore, Cx32, Cx43, and Cx45 may respond differently to ischemic insult in terms of neuroprotection.
American Psychological Association (APA)
Nakase, Taizen& Maeda, Tetsuya& Yoshida, Yasuji& Nagata, Ken. 2009. Ischemia Alters the Expression of Connexins in the Aged Human Brain. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-449559
Modern Language Association (MLA)
Nakase, Taizen…[et al.]. Ischemia Alters the Expression of Connexins in the Aged Human Brain. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-449559
American Medical Association (AMA)
Nakase, Taizen& Maeda, Tetsuya& Yoshida, Yasuji& Nagata, Ken. Ischemia Alters the Expression of Connexins in the Aged Human Brain. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-449559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449559