Similarities and Differences in the Glycosylation Mechanisms in Prokaryotes and Eukaryotes
Joint Authors
Hitchen, Paul G.
Sastre, Federico
Dell, Anne
Galadari, Alaa
Source
International Journal of Microbiology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Recent years have witnessed a rapid growth in the number and diversity of prokaryotic proteins shown to carry N- and/or O-glycans, with protein glycosylation now considered as fundamental to the biology of these organisms as it is in eukaryotic systems.
This article overviews the major glycosylation pathways that are known to exist in eukarya, bacteria and archaea.
These are (i) oligosaccharyltransferase (OST)-mediated N-glycosylation which is abundant in eukarya and archaea, but is restricted to a limited range of bacteria; (ii) stepwise cytoplasmic N-glycosylation that has so far only been confirmed in the bacterial domain; (iii) OST-mediated O-glycosylation which appears to be characteristic of bacteria; and (iv) stepwise O-glycosylation which is common in eukarya and bacteria.
A key aim of the review is to integrate information from the three domains of life in order to highlight commonalities in glycosylation processes.
We show how the OST-mediated N- and O-glycosylation pathways share cytoplasmic assembly of lipid-linked oligosaccharides, flipping across the ER/periplasmic/cytoplasmic membranes, and transferring “en bloc” to the protein acceptor.
Moreover these hallmarks are mirrored in lipopolysaccharide biosynthesis.
Like in eukaryotes, stepwise O-glycosylation occurs on diverse bacterial proteins including flagellins, adhesins, autotransporters and lipoproteins, with O-glycosylation chain extension often coupled with secretory mechanisms.
American Psychological Association (APA)
Dell, Anne& Galadari, Alaa& Sastre, Federico& Hitchen, Paul G.. 2011. Similarities and Differences in the Glycosylation Mechanisms in Prokaryotes and Eukaryotes. International Journal of Microbiology،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-449576
Modern Language Association (MLA)
Dell, Anne…[et al.]. Similarities and Differences in the Glycosylation Mechanisms in Prokaryotes and Eukaryotes. International Journal of Microbiology No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-449576
American Medical Association (AMA)
Dell, Anne& Galadari, Alaa& Sastre, Federico& Hitchen, Paul G.. Similarities and Differences in the Glycosylation Mechanisms in Prokaryotes and Eukaryotes. International Journal of Microbiology. 2011. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-449576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449576