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Association of Immunological Cell Profiles with Specific Clinical Phenotypes of Scleroderma Disease
Joint Authors
Mayayo, Teodoro
Posada, Manuel
Gallardo, Soledad
Rabasco, Antonio María
Lahoz, Carlos
Aguerri, Miriam
López-Cacho, José Manuel
Cárdaba, Blanca
Calzada, David
González-Rodríguez, María Luisa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study aimed to search the correlation among immunological profiles and clinical phenotypes of scleroderma in well-characterized groups of scleroderma patients, comparing forty-nine scleroderma patients stratified according to specific clinical phenotypes with forty-nine healthy controls.
Five immunological cell subpopulations (B, CD4+ and CD8+ T-cells, NK, and monocytes) and their respective stages of apoptosis and activation were analyzed by flow cytometry, in samples of peripheral blood mononuclear cells (PBMCs).
Analyses of results were stratified according to disease stage, time since the diagnosis, and visceral damage (pulmonary fibrosis, pulmonary hypertension, and cardiac affliction) and by time of treatment with corticosteroids.
An increase in the percentages of monocytes and a decrease in the B cells were mainly related to the disease progression.
A general apoptosis decrease was found in all phenotypes studied, except in localized scleroderma.
An increase of B and NK cells activation was found in patients diagnosed more than 10 years ago.
Specific cell populations like monocytes, NK, and B cells were associated with the type of affected organ.
This study shows how, in a heterogeneous disease, proper patient’s stratification according to clinical phenotypes allows finding specific cellular profiles.
Our data may lead to improvements in the knowledge of prognosis factors and to aid in the analysis of future specific therapies.
American Psychological Association (APA)
López-Cacho, José Manuel& Gallardo, Soledad& Posada, Manuel& Aguerri, Miriam& Calzada, David& Mayayo, Teodoro…[et al.]. 2014. Association of Immunological Cell Profiles with Specific Clinical Phenotypes of Scleroderma Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-449595
Modern Language Association (MLA)
López-Cacho, José Manuel…[et al.]. Association of Immunological Cell Profiles with Specific Clinical Phenotypes of Scleroderma Disease. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-449595
American Medical Association (AMA)
López-Cacho, José Manuel& Gallardo, Soledad& Posada, Manuel& Aguerri, Miriam& Calzada, David& Mayayo, Teodoro…[et al.]. Association of Immunological Cell Profiles with Specific Clinical Phenotypes of Scleroderma Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-449595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449595